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KMID : 1123920080220061562
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Korean Journal of Oriental Physiology and Pathology
2008 Volume.22 No. 6 p.1562 ~ p.1565
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Change of Ratio of Onchungeum Composition Induces Different G1 Arrest Mechanisms in Hep3B Cells
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Shin Heung-Mook
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Abstract
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HCMCO5 is a herbal extract which comprises of eight different herbs. We studied whether this prescription has an acute toxicity in rats. SPF Sprague-Dawley male and female rats were administered orally with HMC05 extract of 2,000 mg/kg for 14days. We examined mortality, clinical signs, body weights and gross findings during the tests. The result showed no dead animals. We also could not find a significant body weight changes during the experimental period. In addition, no differences were found between control and HMC05 treated groups in clinical signs and other findings. These results indicate that HMC05 extract did not show any toxic effects, and oral ADL value was over 2,000 mg/kg in SD rats.
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KEYWORD
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HMC05, acute toxicity, mortility, clinical signs, gross findings, ADL
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